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Initial experience with octreotide in the pediatric population
1Department of Child Health, Division of Pediatric Critical Care/Pediatric Anesthesiology, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA.
American Journal of Therapeutics
|November 13, 2001
Summary
Octreotide, a somatostatin analogue, shows therapeutic potential in pediatric patients for conditions like gastrointestinal bleeding and pancreatitis. This study evaluates its use in 10 children, highlighting its impact and dosing.
Area of Science:
- Pediatric Endocrinology
- Gastroenterology
- Pharmacology
Background:
- Octreotide is a somatostatin analogue with established efficacy in adults for various conditions.
- Limited data exists on octreotide's use and safety in pediatric populations.
- Pediatric conditions like hyperinsulinism, gastrointestinal bleeding, and pancreatitis may benefit from octreotide therapy.
Purpose of the Study:
- To retrospectively review the use of octreotide in pediatric patients.
- To evaluate the therapeutic impact and clinical course of octreotide in infants and children.
- To discuss dosing regimens and potential applications of octreotide in pediatric diseases.
Main Methods:
- Retrospective review of 10 pediatric patients (14 days to 17 years) treated with octreotide.
- Octreotide administered via continuous intravenous infusion or intermittent bolus dosing.
- Analysis of clinical outcomes for conditions including gastrointestinal bleeding, pancreatitis, chylous leaks, and hypoglycemia.
Main Results:
- Octreotide was used to treat gastrointestinal bleeding (4 patients), pancreatitis (3 patients), chylous leaks (2 patients), and hypoglycemia (1 patient).
- The study evaluated the clinical course and therapeutic impact of octreotide in these pediatric cases.
- Dosing strategies and potential future applications were also discussed.
Conclusions:
- Octreotide demonstrates potential therapeutic value in managing diverse conditions in pediatric patients.
- Further research is warranted to establish optimal dosing and expand indications for octreotide in children.
- This review contributes to understanding octreotide's role in pediatric medicine.
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