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Caught in the matrix: how vitronectin controls neuronal differentiation

R J Wechsler-Reya1

  • 1Dept of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. rw.reya@duke.edu

Trends in Neurosciences
|November 24, 2001
PubMed

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Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...