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Diastereoselective addition of allylzinc bromide to imines derived from (R)-phenylglycine amide
M van der Sluis1, J Dalmolen, B de Lange
1Syncom B.V., Kadijk 3, 9747 AT Groningen, The Netherlands.
Organic Letters
|November 27, 2001
Abstract:
The highly diastereoselective addition of allylzinc bromide to imines derived from (R)-phenylglycine amide is reported. Homoallylamines with high enantiomeric purity are obtained from the adducts in three steps on removal of the chiral auxiliary by means of a nonreductive protocol. Removal of the auxiliary by hydrogenation leads to the saturated amines, also in high enantiomeric purity. [reaction: see text]