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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Absence of ST7 mutations in tumor-derived cell lines and tumors

K A Hughes1, A F Hurlstone, E S Tobias

  • 1The Cancer Research Campaign Laboratories, Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.

Nature Genetics
|December 1, 2001
PubMed

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...