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Total synthesis of natural product DNA cross-linking agents
1Department of Chemistry, Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA. coleman@chemistry.ohio-state.edu
Current Opinion in Drug Discovery & Development
|December 1, 2001
Abstract:
A variety of naturally occurring compounds interact with duplex DNA by the formation of covalent cross-links. This review describes recent progress on the total synthesis of four natural product families, including the mitomycins, the structurally and functionally related agent FR-900482, the bis-pyrrole isochrysohermidine and the azinomycins.