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Disturbances in hepatocellular function during cardiopulmonary bypass using propofol anaesthesia
1Department of Anesthesiology, Saitama Cardiovascular and Pulmonary Center, 1696 Itai Kounanchyo Osato-gun, Saitama 360-0105, Japan.
European Journal of Anaesthesiology
|December 12, 2001
Summary
Serum hyaluronate levels increase during coronary artery bypass graft surgery, indicating potential liver cell damage. These levels normalize post-surgery, correlating with bilirubin and lactate markers.
Area of Science:
- Cardiovascular Surgery
- Hepatology
- Anesthesiology
Background:
- Serum hyaluronate is a marker for liver cell integrity.
- Changes in serum hyaluronate can indicate liver disorders.
Purpose of the Study:
- To assess changes in serum hyaluronate during coronary artery bypass graft (CABG) surgery.
Main Methods:
- Eleven patients undergoing elective CABG surgery were monitored.
- Hepatic venous oxygen saturation was measured using a specialized catheter.
- Perioperative measurements included hemodynamics, oxygenation, lactate, ketone body ratio, and hyaluronate levels.
Main Results:
- Arterial and hepatic venous hyaluronate levels significantly increased during cardiopulmonary bypass.
- These elevated hyaluronate levels returned to pre-bypass values post-surgery.
- Hyaluronate levels during bypass correlated with total bilirubin and hepatic venous lactate concentrations six hours post-surgery.
Conclusions:
- Cardiopulmonary bypass may disturb hepatocellular integrity, particularly with propofol anesthesia.
- Serum hyaluronate serves as a potential indicator of liver stress during cardiac surgery.