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Contingent negative variation in children with orthostatic dysregulation
1Department of Pediatrics, Nagaoka Red Cross Hospital, Niigata, Japan. torigoe@mail.mynet.ne.jp
Summary
Children with orthostatic dysregulation (OD) experience hypodynamia due to poor motivation and concentration. Treatment for OD significantly improves these cognitive functions and enhances quality of life.
Area of Science:
- Neuroscience
- Pediatrics
- Psychophysiology
Background:
- Children with orthostatic dysregulation (OD) often exhibit hypodynamia, impacting motivation, volition, and concentration.
- These symptoms significantly decrease the quality of life (QOL) in affected children.
- Contingent Negative Variation (CNV) may reflect attention and motivation levels in children with OD.
Purpose of the Study:
- To characterize CNV and post-imperative negative variation in children with OD.
- To assess the relationship between CNV, attention, and motivation in pediatric OD.
- To evaluate the impact of OD on cognitive functions related to psychophysiological responses.
Main Methods:
- Compared CNV in 12 children with OD (aged 10-15) and 23 healthy controls.
- Recorded CNV from Fz, Cz, and Pz sites during a stimulus-response task.
- Utilized a warning stimulus followed by an imperative stimulus with a 2s interstimulus interval.
Main Results:
- Untreated children with OD showed no significant difference in CNV amplitude compared to controls.
- Children with OD treated with midodrine and autonomic training exhibited significantly larger CNV amplitudes.
- Treatment improved early, late, and total CNV at all recorded sites compared to untreated OD patients.
Conclusions:
- Confirms diminished motivation and concentration in children with OD, leading to hypodynamia.
- Treatment for OD effectively improves symptoms, motivation, and concentration, restoring dynamia.
- Recommends OD treatment to ameliorate QOL in affected children.