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Summary
Serum creatine phosphokinase (CPK) levels can help diagnose leptospirosis in jaundiced patients. Elevated CPK with normal transaminases suggests leptospirosis over viral hepatitis.
Area of Science:
- Infectious Diseases
- Hepatology
- Clinical Biochemistry
Background:
- Leptospirosis and viral hepatitis can present with jaundice, complicating diagnosis.
- Distinguishing between these conditions is crucial for appropriate patient management.
- Biochemical markers play a key role in differential diagnosis.
Purpose of the Study:
- To evaluate the diagnostic utility of serum creatine phosphokinase (CPK) and transaminase levels (SGOT, SGPT) in differentiating leptospirosis from viral hepatitis.
- To identify specific enzyme patterns indicative of leptospirosis in jaundiced patients.
Main Methods:
- Serum CPK, SGOT, and SGPT levels were measured during the acute phase of illness.
- 61 patients diagnosed with leptospirosis were compared with 16 patients diagnosed with viral hepatitis.
- Enzyme levels were analyzed to identify significant differences between the two groups.
Main Results:
- Elevated serum CPK levels were observed in 29 out of 61 leptospirosis patients.
- Serum CPK levels were normal in all 16 viral hepatitis patients.
- Leptospirosis patients exhibited lower mean SGOT and SGPT levels compared to viral hepatitis patients.
Conclusions:
- Serum CPK determination is a valuable and simple diagnostic tool for jaundiced patients.
- A pattern of significantly elevated CPK with only moderately elevated transaminases strongly suggests leptospirosis.
- This enzyme profile aids in diagnosing leptospirosis, especially when classic symptoms are absent.
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