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Ophthalmopathy associated with primary hypothyroidism
Acta Endocrinologica
|August 1, 1975
Summary
This study reports on ten patients with primary hypothyroidism and ophthalmopathy, finding thyroid antibodies in most cases. These findings suggest an autoimmune link in patients with both hypothyroidism and ophthalmopathy.
Area of Science:
- Endocrinology
- Immunology
- Ophthalmology
Background:
- Primary hypothyroidism and ophthalmopathy can coexist.
- The relationship between hypothyroidism and ophthalmopathy requires further investigation.
Purpose of the Study:
- To investigate the immunological markers in patients presenting with primary hypothyroidism and ophthalmopathy.
Main Methods:
- Case series of ten patients with primary hypothyroidism and ophthalmopathy.
- Analysis of thyroid antibody titres.
- Detection of long-acting thyroid stimulator (LATS).
- Mouse Harderian gland uptake assay using 35S-sulphate.
Main Results:
- Seven out of ten patients had elevated thyroid antibodies.
- One patient tested positive for LATS.
- One patient showed increased 35S-sulphate uptake in the mouse Harderian gland assay.
Conclusions:
- The presence of thyroid antibodies in a majority of patients suggests an autoimmune etiology for the co-occurrence of hypothyroidism and ophthalmopathy.
- Further research is warranted to elucidate the specific autoimmune mechanisms involved.