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Dynamics of NADPH diaphorase activity in raphe neurons during chronic treatment with opiates
I V Dyuizen1, P A Motavkin, V V Shorin
1Laboratory of Pharmacology, Institute of Sea Biology, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok. iduizen@yahoo.com
Abstract:
Systemic administration of diacetylmorphine considerably reduced the number of NADPH diaphorase-positive (NO-synthesizing) neurons in rat brain raphe nuclei. This effect was blocked by naloxone. In animals with the withdrawal syndrome NO-ergic activity in raphe neurons increased and surpassed the normal.
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