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High intralesional interleukin-10 messenger RNA expression in localized cutaneous leishmaniasis is associated with
E Bourreau1, G Prévot, J Gardon
1Immunologie des Leishmanioses, Institute Pasteur, Cayenne, French Guiana. plaunois@pasteur-cayenne.fr
Abstract:
The intralesional expression of cytokines (interleukin [IL]-4, IL-13, IL-10, and interferon-gamma) was analyzed in 65 patients with localized cutaneous leishmaniasis due to Leishmania guyanensis before specific treatment with pentamidine isethionate. The local expression of IL-10 was significantly higher in patients who responded poorly to treatment than in patients whose lesions were regressing. When an IL-10 level >10 (ratio of the concentration of IL-10 [pg/microL] to that of beta-actin [pg/microL]) was used as an indicator of treatment failure, the sensitivity of this test was 78.6, and the specificity was 72.5. Thus, high intralesional expression of IL-10 might predict a poor response to conventional treatment.