Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epigenetic crosstalk.

I Ben-Porath1, H Cedar

  • 1Department of Cellular Biochemistry, Hebrew University, 91120, Jerusalem, Israel.

Molecular Cell
|December 14, 2001
PubMed
Summary
This summary is machine-generated.

Disrupting histone methylation in the fungus Neurospora crassa erases DNA methylation. This finding reveals how chromatin structure influences DNA methylation patterns and highlights epigenetic crosstalk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of ageing and senescence on pancreatic β-cell function.

Diabetes, obesity & metabolism·2016
Same author

EZH2 promotes a bi-lineage identity in basal-like breast cancer cells.

Oncogene·2012
Same author

Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.

Oncogene·2011
Same author

Gene repression paradigms in animal cells.

Cold Spring Harbor symposia on quantitative biology·2005
Same author

Asynchronous replication and allelic exclusion in the immune system.

Nature·2001
Same author

Developmental regulation of DNA replication timing at the human beta globin locus.

The EMBO journal·2001
Same journal

Biomolecular condensates for proteostasis and potential therapeutic applications.

Molecular cell·2026
Same journal

A negative regulator of mitochondrial complex I assembly adapts respiration to cellular energy demand.

Molecular cell·2026
Same journal

Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection.

Molecular cell·2026
Same journal

Longitudinal monitoring of cytoplasmic RBP-RNA interactions and transcriptome in living cells by engineered protein nanocages.

Molecular cell·2026
Same journal

Structures of the PI3Kα/KRas complex on lipid bilayers reveal molecular mechanisms of PI3Kα activation.

Molecular cell·2026
Same journal

Oligomer disassembly activates an HEPN-containing bacterial defense system.

Molecular cell·2026
See all related articles

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Fungal Genetics

Background:

  • DNA methylation is a crucial epigenetic modification involved in gene regulation.
  • Histone methylation is another key epigenetic mark that influences chromatin structure.
  • The relationship between different epigenetic modifications, such as histone and DNA methylation, is complex and not fully understood.

Purpose of the Study:

  • To investigate the role of histone methylation in regulating DNA methylation in Neurospora crassa.
  • To determine if chromatin structure, influenced by histone methylation, can pattern DNA methylation.
  • To explore the crosstalk between different epigenetic layers.

Main Methods:

  • Utilizing the fungus Neurospora crassa as a model organism.

Related Experiment Videos

  • Employing genetic techniques to disrupt histone methylation.
  • Analyzing DNA methylation levels through molecular assays.

    • Main Results:

    • Disruption of histone methylation led to the complete elimination of DNA methylation.
    • Evidence suggests that chromatin structure directly patterns DNA methylation.
    • The study provides a clear example of epigenetic crosstalk.

    Conclusions:

    • Histone methylation is essential for maintaining DNA methylation in Neurospora crassa.
    • Chromatin structure plays a significant role in directing DNA methylation.
    • This research underscores the intricate interplay between different epigenetic mechanisms.