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Modularity in vertebrate brain development and evolution.

C Redies1, L Puelles

  • 1Institute of Anatomy, University of Essen School of Medicine, Germany. christoph.redies@uni-essen.de

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|December 18, 2001
PubMed
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Brain organization involves embryonic and functional modularity. Cadherins act as an adhesive code, linking positional information to neural circuits and enabling evolutionary adaptability.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Evolutionary Biology

Background:

  • Brain organization is understood through two principles: embryonic modularity and functional modularity.
  • Embryonic modules are histogenetic fields defined by gene expression, leading to brain nuclei and cortical layers.
  • Functional modules are information-processing neural circuits formed by connected brain structures.

Purpose of the Study:

  • To review evidence on how cell adhesion molecules, specifically cadherins, contribute to both embryonic and functional modularity.
  • To explore the role of cadherins in translating positional information into adhesive cues for neural circuit formation.
  • To discuss the implications of brain modularity for evolutionary adaptability.

Main Methods:

  • Review of existing scientific literature and evidence.

Related Experiment Videos

  • Analysis of the role of cadherins in cell adhesion and pattern formation.
  • Integration of concepts from developmental biology and neuroscience.

    • Main Results:

    • Cadherins provide an adhesive code essential for both embryonic and functional modularity.
    • This adhesive code facilitates the transformation of embryonic positional information into functional neural circuits.
    • Preferential homotypic binding of cadherins is a key mechanism.

    Conclusions:

    • Cadherins are crucial for establishing the modular organization of the brain.
    • The translation of embryonic positional cues into adhesive signals shapes functional neural architecture.
    • Brain modularity, mediated by cadherins, may underpin evolutionary adaptability.