Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dosage compensation: do birds do it as well?

Hans Ellegren1

  • 1Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden. Hans.Ellegren@ebc.uu.se

Trends in Genetics : TIG
|December 26, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Divergence in expression of a singing-related neuroplasticity gene in the brains of 2 Ficedula flycatchers and their hybrids.

G3 (Bethesda, Md.)·2024
Same author

Structural genomic variation in the inbred Scandinavian wolf population contributes to the realized genetic load but is positively affected by immigration.

Evolutionary applications·2024
Same author

Highly differentiated loci resolve phylogenetic relationships in the Bean Goose complex.

BMC ecology and evolution·2023
Same author

From high masked to high realized genetic load in inbred Scandinavian wolves.

Molecular ecology·2022
Same author

Whole-genome resequencing of temporally stratified samples reveals substantial loss of haplotype diversity in the highly inbred Scandinavian wolf population.

Genome research·2022
Same author

Major population splits coincide with episodes of rapid climate change in a forest-dependent bird.

Proceedings. Biological sciences·2021
Same journal

The future of marsupial gene editing: What's in the (tool) pouch?

Trends in genetics : TIG·2026
Same journal

Genetic suppressors as new therapeutic targets for Mendelian diseases.

Trends in genetics : TIG·2026
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
Same journal

The myth of asexual fungi.

Trends in genetics : TIG·2026
See all related articles

Bird sex-linked gene expression may be equal between males and females, challenging previous theories. This suggests novel regulatory mechanisms beyond chromosome inactivation are involved in dosage compensation.

Area of Science:

  • Avian genetics
  • Sex chromosome evolution
  • Gene expression regulation

Background:

  • Birds possess distinct sex chromosomes: males are ZZ and females are ZW.
  • Previous hypotheses suggested no dosage compensation for Z-linked genes in birds.
  • Emerging evidence indicates similar expression levels of Z-linked genes between sexes.

Purpose of the Study:

  • To investigate the mechanisms behind potential dosage compensation of Z-linked genes in birds.
  • To explore alternative regulatory pathways if Z chromosome inactivation is not the primary method.

Main Methods:

  • Analysis of gene expression levels for Z-linked genes in male and female birds.
  • Investigation of potential transcriptional upregulation in females or downregulation in males.

Related Experiment Videos

  • Exploration of post-transcriptional or translational regulatory mechanisms.
  • Examination of a novel hypermethylated region on the Z chromosome for regulatory roles.

    • Main Results:

    • Data suggest that male and female birds may exhibit comparable expression levels of Z-linked genes.
    • This finding implies that Z chromosome inactivation is unlikely to be the sole mechanism for equalization.
    • Alternative regulatory strategies, such as differential transcription or translation, are likely involved.

    Conclusions:

    • Avian dosage compensation for Z-linked genes likely involves complex regulatory mechanisms.
    • A newly identified hypermethylated region on the Z chromosome may play a role in this process or sex determination.
    • Further research is needed to elucidate the precise molecular pathways governing Z-linked gene expression in birds.