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BRENDA, enzyme data and metabolic information.
Ida Schomburg1, Antje Chang, Dietmar Schomburg
1University of Cologne, Institute of Biochemistry, Zülpicher Strasse 47, 50674 Köln, Germany. d.schomburg@uni-koeln.de
Nucleic Acids Research
|December 26, 2001
Summary
BRENDA is a comprehensive enzyme database providing functional and molecular information. It serves as a vital resource for biochemical and medical research, aiding in enzyme mechanism and metabolic pathway studies.
Area of Science:
- Biochemistry
- Molecular Biology
- Bioinformatics
Background:
- Enzymes are crucial biological catalysts with diverse functions.
- Access to curated, comprehensive enzyme data is essential for research and development.
- Existing databases may lack the breadth or depth of functional and molecular information.
Purpose of the Study:
- To present BRENDA as a comprehensive relational database for enzyme functional and molecular information.
- To highlight BRENDA's utility in biochemical, medical, and pharmaceutical research.
- To detail the scope and resources available within the BRENDA database.
Main Methods:
- Data extraction and evaluation from approximately 46,000 scientific references.
- Classification of enzyme data according to the IUBMB Enzyme Nomenclature Committee (EC numbers).
- Integration and cross-referencing with other biological databases (organism classification, protein sequences, structures, literature).
Main Results:
- BRENDA contains data for over 40,000 enzymes from more than 6,900 organisms, classified under approximately 3,900 EC numbers.
- Information includes enzyme occurrence, catalyzed reactions, kinetics, substrates, products, inhibitors, cofactors, activators, structure, and stability.
- All data entries are linked to primary literature references, with links to PubMed.
Conclusions:
- BRENDA is a fundamental resource for understanding enzyme mechanisms, metabolic pathways, and metabolic evolution.
- The database supports medicinal diagnostics and pharmaceutical research by providing detailed enzyme properties.
- BRENDA offers academic web access, facilitating broad scientific utilization.