Related Experiment Videos
Neuronal signaling through alternative splicing: some exons CaRRE
1Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. darnelr@rockefeller.edu
Science'S STKE : Signal Transduction Knowledge Environment
|December 26, 2001
Abstract:
Alternative splicing represents a mechanism by which a single gene can be used to create proteins with different functions. Neurons use alternative splicing to produce channels with different sequences and biophysical or regulatory properties. O'Donovan and Darnell discuss a mechanism by which neurons can alter channel splicing in response to neuronal activity through a signal generated by calcium and calcium/calmodulin-dependent kinase activity.