Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central nervous system infection during immunosuppression.

Joseph R Zunt1

  • 1Department of Neurology, University of Washington School of Medicine, Seattle, Washington 98104, USA. jzunt@u.washington.edu

Neurologic Clinics
|January 5, 2002
PubMed
Summary

Human immunodeficiency virus (HIV) infection and immunosuppressive therapy increase central nervous system (CNS) infection risk. Understanding immunosuppression levels and clinical findings aids in diagnosing and treating CNS infections in immunocompromised patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human T Cell Lymphotropic Virus Type 1 and Human T Cell Lymphotropic Virus Type 2 Mortality in the Shipibo-Konibo People.

The American journal of tropical medicine and hygiene·2025
Same author

Quantitative analysis of HSV‑1 shedding as a predictor of cerebral vasospasm severity in patients with subarachnoid hemorrhage.

Biomedical reports·2024
Same author

Sex Differences in the Risk of Stroke Associated With Traditional and Non-Traditional Factors in a US Cohort of People With HIV Infection.

Neurology·2024
Same author

Building Equitable Neuroscience Research Collaborations in Resource-limited Settings.

Seminars in neurology·2024
Same author

Outcomes and Experiences of Patients and Their Caregivers After Severe Stroke Requiring Tube Feeding in Peru.

Journal of pain and symptom management·2024
Same author

Scoping review of measures of treatment burden in patients with multimorbidity: advancements and current gaps.

Journal of clinical epidemiology·2023

Area of Science:

  • Neuroscience
  • Immunology
  • Infectious Diseases

Background:

  • Immunosuppression from human immunodeficiency virus (HIV) or transplantation increases susceptibility to central nervous system (CNS) infections.
  • The degree and type of immunosuppression significantly influence the presentation of CNS infections.

Purpose of the Study:

  • To discuss how a suppressed immune status alters the clinical and radiologic presentation of selected CNS infections.
  • To outline diagnostic approaches and recommended treatments for CNS infections in immunocompromised individuals.

Main Methods:

  • Review of clinical and radiologic findings in patients with CNS infections and varying levels of immunosuppression.
  • Analysis of how immunosuppression modifies the typical presentation of common CNS pathogens.

Related Experiment Videos

Main Results:

  • Specific patterns of immunosuppression correlate with increased risk and altered presentation of CNS infections.
  • Clinical and radiologic data are crucial for differentiating infectious etiologies in immunocompromised hosts.

Conclusions:

  • Assessing the level and type of immunosuppression is vital for diagnosing CNS infections.
  • Tailoring diagnostic and treatment strategies to the host's immune status improves patient outcomes.