[Familial syringoma: a rare clinical variant]

Area of Science:

• Dermatology
• Genetics

Background:

• Syringomas are benign adnexal tumors typically presenting sporadically.
• Common forms include localized periorbital or truncal eruptive patterns.

Observation:

• Two families with rare hereditary syringomas were identified.
• Lesions appeared during puberty with variable distribution (periorbital, facial, truncal, extremities).

Findings:

• Autosomal dominant inheritance pattern is suggested, affecting both sexes.
• The incidence of familial syringomas might be underestimated in the general population.

Implications:

• Recognizing hereditary patterns is crucial for accurate diagnosis and genetic counseling.
• Effective treatment options include carbon dioxide laser and specialized surgical techniques for improved cosmetic outcomes.