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[Use of radionuclides in therapy]
1Institut za nuklearne nauke Vinca, Laboratorija za radioizotope, 11001 Beograd. cilevu@eunet.yu
Medicinski Pregled
|January 5, 2002
Summary
This review covers the selection, properties, and production of therapeutic radionuclides for nuclear medicine. While common radionuclides like 131I are readily available, many novel agents require further development for routine clinical use.
Area of Science:
- Nuclear medicine
- Radiopharmaceutical therapy
- Radionuclide selection
Context:
- Therapy relies on targeted radiation delivery using radionuclides.
- Selection criteria include physical, chemical, and biological properties for optimal therapeutic effect.
- Applications primarily in oncology and rheumatology.
Purpose:
- To review criteria for selecting therapeutic radionuclides.
- To discuss properties and production methods of radiotherapeuticals.
- To assess the availability of established and novel radionuclides.
Summary:
- Radiotherapeutics are selected based on LET, RBE, and pharmacokinetic properties.
- Commonly used radionuclides (32P, 89Sr, 90Y, 131I) are produced in reactors or cyclotrons.
- Emerging radionuclides require further investigation for routine production and availability.
Impact:
- Informs the selection of optimal radionuclides for targeted cancer therapy.
- Highlights production challenges and availability issues for novel radiotherapeutics.
- Facilitates advancements in nuclear medicine by addressing radionuclide development needs.