Related Experiment Video
Updated: Jul 26, 2026
10:34
Characterization and Application of Passive Samplers for Monitoring of Pesticides in Water
Published on: August 3, 2016
Development of a personal isocyanate sampler based on DBA derivatization on solid-phase microextraction fibers
Fresenius' Journal of Analytical Chemistry
|January 5, 2002
Summary
A new portable sampler using SPME fibers effectively detects isocyanates. This method offers a low detection limit, crucial for occupational safety and health monitoring.
Area of Science:
- Analytical Chemistry
- Environmental Science
- Occupational Health
Background:
- Isocyanates are hazardous airborne compounds requiring accurate monitoring.
- Existing monitoring methods may lack portability or sensitivity.
- Occupational exposure limits necessitate sensitive and reliable detection techniques.
Purpose of the Study:
- To design and evaluate a portable diffusive sampler for isocyanates.
- To assess the sampler's performance against established occupational exposure limits.
- To provide a practical tool for isocyanate exposure assessment.
Main Methods:
- Utilized dibutylamine (DBA) loaded onto polydimethylsiloxane-divinylbenzene (PDMS-DVB) solid-phase microextraction (SPME) fibers.
- Analyzed DBA-isocyanate derivatives via LC-MS with atmospheric pressure chemical ionization (APCI).
- Calibrated samplers using hexamethylene diisocyanate (HDI) in a gas-generation chamber to determine uptake rate.
Main Results:
- Achieved an uptake rate of 1.13 pg (min ppb(v))(-1) at 25°C.
- Established a method detection limit of 3.2 µg m⁻³.
- Detection limit is below 10% of NIOSH and ACGIH time-weighted average (TWA) exposure limits.
Conclusions:
- The developed portable diffusive sampler demonstrates high sensitivity for isocyanate detection.
- The method is suitable for monitoring airborne isocyanate concentrations relative to occupational safety standards.
- Considerations for practical application of the SPME device as a diffusive sampler are discussed.
