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Pulsatile drug-delivery systems.

T Bussemer1, I Otto, R Bodmeier

  • 1College of Pharmacy, Freie Universität Berlin, Germany.

Critical Reviews in Therapeutic Drug Carrier Systems
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

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Pulsatile drug delivery systems offer advantages over continuous release for drugs with high first-pass effects or specific timing needs. These systems provide a lag time before rapid drug release, enhancing therapeutic outcomes.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Conventional continuous drug release is suboptimal for certain medications.
  • Drugs with high first-pass metabolism or chronopharmacological needs benefit from alternative delivery.
  • Pulsatile drug release offers a promising alternative.

Purpose of the Study:

  • To review oral pulsatile drug delivery systems.
  • To focus on time-controlled release mechanisms.
  • To highlight systems suitable for specific drug release profiles.

Main Methods:

  • Review of existing literature on pulsatile drug delivery.
  • Classification of pulsatile systems based on release control (site-specific vs. time-controlled).
  • Emphasis on the mechanisms governing time-controlled release.

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Main Results:

  • Pulsatile release is defined by a lag time followed by rapid drug release.
  • Systems can be site-specific (pH/enzyme-triggered) or time-controlled (system-dependent).
  • Various single- and multiple-unit oral systems exist.

Conclusions:

  • Pulsatile drug delivery systems are increasingly important for specific therapeutic needs.
  • Time-controlled systems offer predictable drug release independent of environmental factors.
  • Further development in pulsatile systems can optimize drug efficacy and patient compliance.