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[Myelotoxicity of a plant cytostatic preparation etoposide]
A M Dygaĭ1, E V Udut, V V Zhdanov
1Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|January 5, 2002
Abstract:
The myelotoxicity and the hemopoiesis recovery effect of etoposide, an antitumor preparation of the podophyllotoxin group, were experimentally studied on mice. It was found that the main role in the hemopoiesis recovery after etoposide administration is related to accelerated proliferation and increased differentiation of the hemopoietic precursor cells.