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Related Experiment Videos

Cell differentiation lineage in the prostate.

Y Wang1, S Hayward, M Cao

  • 1Department of Anatomy, University of California, San Francisco, 94143-0452, USA.

Differentiation; Research in Biological Diversity
|January 5, 2002
PubMed
Summary
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Prostate stem cells in embryonic and adult prostates share similar differentiation markers, originating from the embryonic urogenital sinus epithelium. These rare adult basal cells maintain an embryonic profile, differentiating into luminal and basal cells.

Area of Science:

  • Urology
  • Developmental Biology
  • Cell Biology

Background:

  • Prostatic epithelium comprises luminal and basal cells, originating from common progenitor/stem cells.
  • Progenitor/stem cells are hypothesized to be concentrated in embryonic urogenital sinus epithelium.
  • These cells are also proposed to exist within the basal compartment of adult prostatic epithelium.

Purpose of the Study:

  • To investigate the differentiation markers of embryonic and adult prostatic progenitor/stem cells.
  • To determine if embryonic and adult progenitor/stem cells share similar differentiation marker profiles.
  • To identify the progenitor/stem cell population within the adult prostate.

Main Methods:

  • Immunohistochemical analysis of cytokeratin (CK) 8, 18, 14, 5, 19, p63, and glutathione-S-transferase-pi (GSTpi) expression.

Related Experiment Videos

  • Examination of embryonic urogenital sinus epithelium and developing prostatic epithelium (rat, mouse, human).
  • Analysis of adult rodent and human prostatic basal and luminal epithelial cells.

    • Main Results:

    • Embryonic prostatic epithelium co-expressed luminal (CK8, CK18), basal (CK14, CK5, p63), and intermediate (CK19, GSTpi) markers.
    • Adult luminal cells predominantly expressed luminal markers (CK8, CK18).
    • A subset of adult basal cells co-expressed basal, luminal, and intermediate markers, similar to embryonic cells, identifying them as potential progenitor/stem cells.

    Conclusions:

    • Prostatic epithelial progenitor/stem cells maintain a differentiation marker profile similar to embryonic urogenital sinus epithelium throughout development.
    • Adult progenitor/stem cells reside in the basal compartment and co-express luminal, basal, and intermediate cell markers.
    • These progenitor/stem cells differentiate into mature luminal cells (CK8+, CK18+) or basal cells (CK5+, CK14+, p63+, CK19+, GSTpi+).