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Published on: April 7, 2021
[Experimental study of partial liquid ventilation in rabbits with acute lung injury]
1Department of Respiratory Disease, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China.
Objective:
To observe the effectiveness of partial liquid ventilation (PLV) on gas exchange, pulmonary compliance (Cst), blood dynamics in the oleic acid (OA) induced acute lung injury (ALI) rabbits.
Methods:
24 healthy male New Zealand rabbits were randomly allocated to three groups and treated with various methods after OA acute lung injury model established. The study groups as follows: PEEP group with conventional mechanical ventilation (CMV) and PEEP, normal saline (NS) group with CMV, PEEP and NS, FDC group with CMV, PEEP and FDC. The parameters such as blood gases, Cst, circulation state were observed before and after treatment.
Results:
In FDC group, PaO2 increased from (90 +/- 6) mm Hg to (232 +/- 26) mm Hg(P < 0.05), PaCO2 decreased from (52.1 +/- 2.8) mm Hg to (40.1 +/- 3.0) mm Hg (P < 0.05), Cst increased from (1.05 +/- 0.11) ml/cm H2O to (1.79 +/- 0.24) ml/cm H2O(P < 0.05). HR, MAP and CVP showed no significant changes after treatment compared with pretreatment values in FDC group.
Conclusion:
Pulmonary gas exchange and pulmonary compliance improved significantly during PLV in the ALI rabbits, without obvious influence on hemodynamic status.
