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Updated: Aug 4, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results
1Department of Neurosciences, UCSD School of Medicine, and Neurology, Veterans Administration Medical Center, San Diego, CA, USA. plyden@ucsd.edu
Stroke
|January 10, 2002
Summary
Clomethiazole did not improve outcomes for patients experiencing major ischemic stroke. This large clinical trial found no significant benefit compared to placebo, despite early administration.
Area of Science:
- Neurology
- Clinical Trials
- Stroke Medicine
Background:
- A prior study suggested clomethiazole may benefit major ischemic stroke patients.
- This hypothesis was tested in a larger, randomized controlled trial.
Purpose of the Study:
- To evaluate the efficacy of clomethiazole in treating major ischemic stroke.
- To determine if clomethiazole improves functional outcomes in patients with total anterior circulation syndrome.
Main Methods:
- 1198 patients with major ischemic stroke were randomized to receive clomethiazole or placebo.
- Treatment was initiated within 12 hours of symptom onset.
- Functional outcomes were assessed using the Barthel Index at 90 days.
Main Results:
- No significant difference in Barthel Index scores was observed between clomethiazole and placebo groups (42% vs. 46%).
- Clomethiazole showed no efficacy on secondary outcome measures, including neurological scales and infarct volume.
- Somnolence was a common adverse event in the clomethiazole group.
Conclusions:
- Clomethiazole is not effective in improving outcomes for patients with major ischemic stroke.
- The study did not support the initial hypothesis regarding clomethiazole's therapeutic potential in this patient population.
Related Concept Videos
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:26Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...