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Effects of type 1A serotonin receptor agonist 8-OH-DPAT on immune response
G V Idova1, M A Cheido, E N Zhukova
1Laboratory of Mechanisms of Neurochemical Modulation, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. galina@iph.ma.nsc.ru
Bulletin of Experimental Biology and Medicine
|January 10, 2002
Abstract:
The selective agonist of type 1 A serotonin receptors 8-hydroxy-2-(di-n-propyl-amino)tetra-lin (8-OH-DPAT) suppressed the immune response. Intraperitoneal administration of 1 mg/kg 8-OH-DPAT to Wistar rats over 2 days after immunization decreased the count of plaque- and rosette-forming cells on day 5. Our results indicate that type 1A serotonin receptors are involved in the realization of the immunosuppressive effects of the serotoninergic system.