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Related Experiment Videos

Hemolysis with red cell covered surfaces.

R W Benedict, M C Williams

    Biomaterials, Medical Devices, and Artificial Organs
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Ammonia glow discharge-activated polypropylene (PP) surfaces reduced red blood cell hemolysis. Activated PP surfaces without cells showed the best performance, decreasing hemolysis by 20% compared to virgin PP.

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    Area of Science:

    • Biomaterials Science
    • Surface Chemistry
    • Hemolysis Research

    Background:

    • Polypropylene (PP) is widely used in biomedical devices.
    • Understanding surface interactions with biological components like red blood cells is crucial for device safety and efficacy.
    • Red blood cell hemolysis is a key indicator of blood-surface incompatibility.

    Purpose of the Study:

    • To evaluate the hemolytic properties of red blood cells on ammonia glow discharge-activated polypropylene (PP) surfaces.
    • To compare the hemolysis induced by untreated PP, activated PP with varying red cell coatings, and activated PP without cells.

    Main Methods:

    • PP disks were activated using ammonia glow discharge.
    • Red blood cells were deposited onto PP disks from saline suspensions.

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  • Some cell-coated disks were fixed with glutaraldehyde.
  • Hemolysis was induced and measured using a rotational blood-shearing device.
  • Hemolysis was compared between different surface treatments and cell coatings.

    • Main Results:

    • Uniform, dense red cell coatings on glutaraldehyde-fixed surfaces showed 10% less hemolysis than virgin PP.
    • Non-fixed cells and secondary cell layers increased hemolysis.
    • Gamma-globulin coatings reduced hemolysis.
    • Activated PP surfaces without cells exhibited the lowest hemolysis, approximately 20% less than virgin PP.

    Conclusions:

    • Ammonia glow discharge activation significantly reduces red blood cell hemolysis on PP surfaces.
    • Activated PP surfaces without cellular coatings offer the best hemocompatibility.
    • Cellular interactions and detachment dynamics play a critical role in surface-induced hemolysis.