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Antiestrogenic activity of 4-methyl-7-hydroxy-6,8-substituted coumarins
Research Communications in Chemical Pathology and Pharmacology
|August 1, 1975
Abstract:
Eight 4-methyl-7-hydroxy-6,8-substituted coumarins were synthesized and evaluated for antiestrogenic activity. All coumarins, possessing approximate LD50 values of 500 - greater than 800 mg/kg, antagonized the uterotropic effects of diethylstilbestrol (DES) in female rats.
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