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Mycobacterium-specific human CD8 T cell responses
1Tuberculosis Research Programme, Medical Research Council (MRC) Laboratories, Banjul, The Gambia, West Africa. mklein@mrc.gm
Archivum Immunologiae Et Therapiae Experimentalis
|January 19, 2002
Abstract:
Tuberculosis (TB) remains a global health problem. There is an intense effort to identify correlates of protective immunity and to design new TB vaccines. CD8 T cells are thought to play a significant role in controlling Mycobacterium tuberculosis infection. Relatively little has been published about the antigens and epitopes targeted by mycobacteria-specific CD8 T cells. Here we present an update of our 1999 overview of human CD8 T cell epitopes in mycobacterial antigens and discuss related issues relevant to TB diagnosis and vaccine development.