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Related Experiment Videos

Inulin as filler-binder for tablets prepared by direct compaction.

Anko C Eissens1, Gerad K Bolhuis, Wouter L J Hinrichs

  • 1Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. A.C.Eissens@farm.rug.nl

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|January 23, 2002
PubMed
Summary
This summary is machine-generated.

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Amorphous inulin with entrapped air exhibits favorable tabletting properties, acting as a viable alternative to conventional excipients. Its lubricant sensitivity and dissolution characteristics depend on particle properties and chain length.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Amorphous inulin is a potential pharmaceutical excipient.
  • Understanding its tabletting properties is crucial for formulation development.

Purpose of the Study:

  • To investigate the tabletting properties of various amorphous inulin types.
  • To correlate these properties with chain length, particle size, and entrapped air content.

Main Methods:

  • Evaluation of powder flow and density.
  • Compactibility assessment using a compaction simulator.
  • Analysis of lubricant sensitivity and tablet disintegration/dissolution.

Main Results:

  • Improved powder flow with increased particle size.

Related Experiment Videos

  • High bonding capacity across all inulin types.
  • Lubricant sensitivity varied, being high for inulins with low entrapped air and low for those with high entrapped air.
  • Tablets dissolved rather than disintegrated, with dissolution time inversely related to chain length.

    • Conclusions:

    • Amorphous inulin with significant entrapped air demonstrates good filler-binder capabilities.
    • Inulin's properties suggest it as an attractive alternative to common pharmaceutical excipients.
    • Chain length influences dissolution, offering potential for specific dosage forms like chewable tablets.