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Combination therapy including pentoxifylline for entero-Behçet's disease
T Hisamatsu1, H Kishikawa, H Fukuya
1Department of Internal Medicine, Ichikawa General Hospital, Tokyo Dental College, 5-11-13, Sugano, Ichikawa, Chiba 272-8513, Japan.
The Bulletin of Tokyo Dental College
|January 25, 2002
Summary
Pentoxifylline combination therapy effectively treated three patients with entero-Behçet
Area of Science:
- Gastroenterology
- Rheumatology
- Immunology
Background:
- Behçet's disease is a chronic vasculitis with potential multi-organ involvement.
- Entero-Behçet's disease presents as a severe, relapsing form with risks of bleeding and perforation.
Observation:
- Three female patients with entero-Behçet's disease were treated with a combination therapy including pentoxifylline (600 mg/day).
- Clinical symptoms, C-reactive protein levels, and endoscopic findings were monitored.
Findings:
- All patients showed immediate improvement in clinical symptoms and reduced C-reactive protein levels.
- Endoscopic evaluation revealed significant healing or reduction of intestinal lesions in all treated patients.
Implications:
- Combination therapy with pentoxifylline demonstrates clinical efficacy in managing entero-Behçet's disease.
- This therapeutic approach may offer a viable treatment option for patients with this challenging condition.