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[Polyarteritis nodosa and hepatitis B infection treated with lamivudine]
Tine Münster1, Nina M Weis, Kim Krogsgaard
1Infektionsmedicinsk afdeling, H:S Hvidovre Hospital, klinisk forskningsenhed.
Ugeskrift for Laeger
|January 31, 2002
Abstract:
A 36-year-old man was diagnosed with polyarteritis nodosa (PAN). He presented with weight loss, hypertension, and mono-neuritis. Pneumoperitoneum and septicaemia developed and laparotomy revealed necrosis of a segment of the ileum. The patient was HBsAg/HBeAg and HBV DNA positive. Liver biopsy showed active cirrhosis. The PAN symptoms remitted upon treatment with prednisolone and lamivudine. Seroconversion from HBeAg to anti-HBe occurred six months later. One year after the end of treatment, the patient was still HBeAg and HBV DNA negative, with normal liver enzymes and no symptoms of PAN.