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Central nervous system anomalies.

R A Bronsteen1, C H Comstock

  • 1Division of Fetal Imaging, Department of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak, Michigan, USA.

Clinics in Perinatology
|January 31, 2002
PubMed
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Fetal central nervous system abnormalities often indicate increased fetal aneuploidy and other defects. Early diagnosis necessitates a thorough search for associated anomalies and genetic testing for better pregnancy prognosis.

Area of Science:

  • Fetal Medicine
  • Neurodevelopmental Pediatrics
  • Prenatal Diagnostics

Background:

  • Fetal central nervous system (CNS) abnormalities represent diverse lesions.
  • These anomalies are frequently linked to elevated rates of fetal aneuploidy.
  • Associated anomalies, both within and outside the CNS, are common.

Purpose of the Study:

  • To highlight the significance of fetal CNS abnormalities.
  • To emphasize the association with aneuploidy and other fetal defects.
  • To underscore the importance of comprehensive evaluation and genetic testing.

Main Methods:

  • Review of existing literature on fetal CNS abnormalities.
  • Analysis of associated findings and their impact on prognosis.
  • Discussion of diagnostic and genetic evaluation protocols.

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Main Results:

  • Fetal CNS lesions often occur with increased fetal aneuploidy.
  • A higher incidence of concurrent anomalies is observed.
  • Prognosis is influenced by both the primary lesion and associated findings.

Conclusions:

  • Antenatal diagnosis of CNS abnormalities requires a meticulous search for other defects.
  • Genetic evaluation and testing are crucial considerations.
  • Integrated assessment improves understanding of pregnancy outcomes.