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Regulatory context is a crucial part of gene function
Sabine Fessele1, Holger Maier, Christian Zischek
1Medizinische Poliklinik der Ludwig-Maximilians-Universität München, Schillerstr. 42, D-80336, Munich, Germany.
Trends in Genetics : TIG
|January 31, 2002
Abstract:
Information about the time and place of gene transcription, which until recently was only possible by extensive experimental analysis, can now be predicted through in silico analysis. Using the human RANTES/CCL5 promoter, we show that organizational features of promoters derived from promoter sequences contain information about the spatial and temporal 'functional context' of expression.