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Updated: Apr 23, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
Published on: December 28, 2017
Role of PET in Radiation Oncology: A Theranostic Perspective on Detection of Radiation-Induced Complications
Ehsan Ranjbar1, Dia Avalur1, Mukesh Kandra2
1Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Abstract:
Radiation therapy remains essential in managing thoracic and head and neck malignancies, yet radiation-induced injury to surrounding normal tissues continues to pose significant clinical challenges. Traditional assessment of radiation complications relies on clinical symptoms and anatomic imaging, often detecting injury only after irreversible damage has occurred. This article reviews the emerging role of fluorodeoxyglucose PET/computed tomography (FDG-PET/CT) as a theranostic tool for early detection and quantitative assessment of radiation-induced complications across multiple organ systems. FDG-PET/CT exploits the increased glycolytic activity of inflamed tissues to identify subclinical radiation-induced injury to the surrounding healthy tissue before the onset of clinical symptoms.
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