Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Persantine improves acute pancreatitis in vitro.

A Yu1, Z Vona-Davis, X Zhu

  • 1Department of Surgery, West Virginia University School of Medicine, Morgantown, USA.

The West Virginia Medical Journal
|February 7, 2002
PubMed
Summary

Persantine, a vasodilator, shows promise in treating acute pancreatitis (AP). This study found that persantine significantly reduced amylase production, a key marker of AP, in cell cultures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to 'Cyclosporine A protects against wasp venom-induced rhabdomyolysis in rats by inhibiting the CypD-mPTP pathway' [Toxicon 281 (2026) 109187].

Toxicon : official journal of the International Society on Toxinology·2026
Same author

A blinded randomised split-body clinical trial evaluating the effect of fluorescent light energy on antimicrobial management of canine interdigital furunculosis.

Veterinary dermatology·2025
Same author

Light-Activatable, Cell-Type Specific Labeling of the Nascent Proteome.

ACS chemical neuroscience·2024
Same author

Feasibility study of the multishot gradient-echo planar imaging sequence in non-enhanced and free-breathing whole-heart magnetic resonance coronary angiography.

Clinical radiology·2023
Same author

The petrosal artery and its variations: a comprehensive review and anatomical study with application to skull base surgery and neurointerventional procedures.

Folia morphologica·2022
Same author

Substantial oxygen consumption by aerobic nitrite oxidation in oceanic oxygen minimum zones.

Nature communications·2021

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Acute pancreatitis (AP) is a serious inflammatory condition of the pancreas.
  • Current treatments for AP are limited, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To investigate the potential of persantine, a vasodilator, in ameliorating acute pancreatitis (AP) in an in vitro model.
  • To determine the efficacy of persantine in reducing pancreatic inflammation markers.

Main Methods:

  • Rat pancreatic ductal cells were cultured and treated to induce AP using cerulein or TNF-a.
  • Persantine was administered at various concentrations (0.1 uM to 100 uM) after induction of AP.
  • Amylase production, a marker of pancreatic damage, was measured to assess AP severity.

Main Results:

Related Experiment Videos

  • Both cerulein and TNF-a significantly increased amylase production, confirming AP induction.
  • Persantine treatment significantly decreased amylase production in cerulein-induced AP at 100 uM.
  • Persantine demonstrated efficacy in TNF-a-induced AP at lower concentrations (0.1 uM and 1 uM).

Conclusions:

  • Persantine effectively ameliorates experimental acute pancreatitis in vitro.
  • The vasodilator persantine represents a potential therapeutic agent for managing AP.
  • This study provides the first evidence of persantine's beneficial effects on AP models.