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[Slow transit constipation treated by surgery: analysis of 17 cases]
1Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|February 7, 2002
Summary
Colectomy effectively treats severe slow transit constipation (STC) in patients with long-term laxative abuse. Simultaneous treatment of outlet obstructive constipation (OOC) is recommended for optimal outcomes.
Area of Science:
- Gastroenterology
- Colorectal Surgery
Context:
- Slow transit constipation (STC) is a debilitating condition characterized by infrequent bowel movements.
- Long-term laxative abuse and outlet obstructive constipation (OOC) are frequently associated with STC.
- Pathological changes in the myenteric plexus, including reduced neurons and axonal degeneration, are observed in STC patients.
Purpose:
- To investigate the surgical indications, prognosis, and potential pathogenic factors of STC.
- To evaluate the effectiveness of colectomy in managing STC.
- To identify associated conditions and pathological findings in STC.
Summary:
- A retrospective analysis of 17 STC patients who underwent colectomy revealed significant improvements in bowel movement frequency.
- Colectomy demonstrated high efficacy in alleviating STC symptoms, with 82.4% of patients also having OOC and 50% exhibiting abnormal sex hormones.
- Pathological examination showed reduced argyrophilic neurons and axonal vacuolar degeneration in the myenteric plexus.
Impact:
- Colectomy offers a highly effective treatment for refractory STC.
- Simultaneous management of OOC is crucial for successful STC treatment.
- Understanding the pathophysiology of STC can guide future therapeutic strategies.