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Transverse process fusion with bovine anorganic bone
Edmund H Frank1, Xi Gong, Richard V Sipe
1Department of Neurosurgery, Oregon Health Sciences University, 3181SW Sam Jackson Park Road, Portland, OR 97201, USA. franke@OHSU.edu
Journal of Biomedical Materials Research
|February 9, 2002
Summary
Bovine anorganic bone combined with a collagen membrane effectively promotes spine fusion in rabbits, offering a promising alternative to autografts for spinal fusion procedures.
Area of Science:
- Orthopedics
- Biomaterials Science
- Spinal Surgery
Background:
- Spinal fusion aims to achieve bony union between vertebrae.
- Autografts are the gold standard but have limitations.
- Novel bone graft substitutes are needed for spinal fusion.
Purpose of the Study:
- To evaluate the efficacy of bovine anorganic bone with a collagen membrane for spine fusion.
- To compare this combination to autograft and other controls in a rabbit model.
Main Methods:
- A rabbit spine fusion model using decortication of transverse processes.
- Groups received no treatment, autograft, collagen membrane, anorganic bone, or anorganic bone plus collagen membrane.
- Radiographic and histological analyses were performed at 6 weeks.
Main Results:
- Anorganic bone alone migrated, but with a collagen membrane, it stayed localized.
- Significant transverse process fusion was achieved with anorganic bone and collagen membrane.
- Autograft showed the most new bone formation, but the combination was effective.
Conclusions:
- Bovine anorganic bone combined with a collagen membrane facilitates osseous fusion in spine surgery.
- This combination is a viable alternative to autografts for spinal fusion.
- Further studies are needed to assess long-term feasibility and biomechanics.