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Updated: Oct 2, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
1Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, United Kingdom.
Abstract:
The results of applying a fragment-based protein tertiary structure prediction method to the prediction of 8 CASP4 targets are described. The method is based on the assembly of supersecondary structural fragments taken from highly resolved protein structures using a simulated annealing algorithm. Despite the significant degree of success in this case, there is clearly much more developmental work required before predictions with the accuracy of a good homology model, or even a good fold recognition model, can be made with use of this kind of approach.
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