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[Protect intercellular communication of pigment epithelium after laser photocoagulation]
Objective:
To observe the protective effect on the intercellular communication of retinal pigment epithelial (RPE) cells of dexamethasone (Dex) and verapamil (Ver) at different concentrations after laser photocoagulation.
Method:
Ten pig eyes were used to culture pig pigment epithelium cells. Use different concentrations of Dex and Ver to incubate cultured RPE cells 2 hours before laser coagulation, and then measure the intercellular communication function of confluent cells surrounding the coagulation spots after photocoagulation.
Result:
125 mg/L Dex and 20 mg/L Ver could protect the intercellular communication of RPE cells under laser photocoagulation. The high concentration of drugs had better result.
Conclusion:
Both Dex and Ver can preserve the intercellular communication in vitro. The protective capacity is related to the concentration of drug.
