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[Antipsoriatic effect of dithranol (anthralin). 1]
Summary
This review explores anthralin's biochemical effects, highlighting its enzyme inhibition and impact on nucleic acid metabolism for psoriasis treatment. It confirms anthralin is effective with UV light but less so in zinc paste.
Area of Science:
- Biochemistry
- Pharmacology
- Dermatology
Context:
- Psoriasis involves disturbed skin metabolism.
- Anthralin (dithranol) is a therapeutic agent for psoriasis.
Purpose:
- To review the biochemical-pharmacological actions of anthralin.
- To discuss the regulation of disturbed metabolism in psoriasis.
Summary:
- Anthralin exhibits enzyme inhibition, blocks nucleic acid metabolism, and demonstrates cytostatic-cytotoxic effects.
- It specifically inhibits key enzymes in the pentose phosphate pathway.
- In vitro studies support clinical findings regarding anthralin's efficacy with UV light and reduced effectiveness in zinc paste.
Impact:
- Provides insights into anthralin's mechanism of action in psoriasis.
- Informs therapeutic strategies for psoriasis management.
- Highlights the importance of formulation and combination therapies.