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Identification and sequencing of the HLA-B*4106 allele
S Vidal1, M P Morante, A M Mosquera
1Department of Immunology, Hospital Sant Pau and Inst. Rec. Sant Pau, Barcelona, Spain. Svidal@hsp.santpau.es
Tissue Antigens
|February 15, 2002
Abstract:
We report a novel HLA-B*41 allele (HLA-B*4106) initially detected by an unusual sequence-specific oligonucleotide (SSO) hybridization pattern and identified by sequence-based HLA typing. Molecular cloning and sequencing determined that the new HLA-B allele was identical to the HLA-B*4101 in exon 2 and 3 except for a single nucleotide substitution in the exon 3 changing codon 204 from Glu to Gln (GAG-->CAG). In addition, intron 2 was identical to the published HLA-B*4104 intron 2, except for the base 509 (C-->G).