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Determination of Three Acetylator Phenotypes in a Mexican Population Using Sulfamethazine Metabolic Ratio
G. Castañeda-Hernández1, A. Falcón-Neri, A. Herrera-Abarca
1Sección de Terapéutica Experimental, Departamento de Farmacologia y Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, D.F., Mexico.
Abstract:
Eighty-six Mexican young healthy volunteers received a 500-mg oral sulfamethazine dose. Urine was collected 0--6 h after medication and acetylated, and unchanged sulfamethazine were determined by the Bratton--Marshall method. The frequency distribution of acetylated/unchanged sulfamethazine, determined by probit analysis, appeared to be trimodal, allowing the discrimination of three acetylator phenotypes. The frequencies of rapid, intermediate, and slow acetylators were 28%, 42%, and 30% respectively, being consistent with the Hardy-Weinberg law.