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Adrenocortical reserve in patients with active tuberculosis
A H Zargar1, F A Sofi, M A Akhtar
1Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India.
JPMA. the Journal of the Pakistan Medical Association
|February 20, 2002
Summary
Active tuberculosis patients show reduced adrenal cortical reserve, impacting their health outcomes. This diminished reserve correlates with disease severity and duration in tuberculosis patients.
Area of Science:
- Endocrinology
- Infectious Diseases
- Pulmonology
Background:
- Studies indicate reduced adrenal cortical reserve in active tuberculosis patients.
- This compromised reserve may contribute to increased mortality and morbidity.
Purpose of the Study:
- To investigate adrenal cortical reserve in active tuberculosis.
- To examine the relationship between adrenal reserve, disease duration, and severity.
Main Methods:
- Adrenocorticotropic hormone (ACTH) stimulation test administered to 40 tuberculosis patients and 10 healthy controls.
- Measured basal serum cortisol and stimulated cortisol response parameters.
Main Results:
- Tuberculosis patients exhibited significantly lower stimulated cortisol response compared to controls.
- Adrenocortical reserve inversely correlated with radiological severity and disease chronicity.
- 35% of patients showed sub-optimal cortisol response to ACTH stimulation.
Conclusions:
- Active tuberculosis is associated with diminished adrenocortical reserve.
- Reduced adrenal reserve is linked to increased disease severity and duration in tuberculosis.