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Frequency of adverse drug reactions in children: a prospective study
Annie Pierre Jonville-Béra1, Bruno Giraudeau, Pascal Blanc
1Department of Clinical Pharmacology and Regional Drug Monitoring Centre, University Hospital of Tours, 2 boulevard Tonellé, 37044 Tours Cedex, France. jonville-bera@chu-tours.fr
Aims:
To assess the frequency of adverse drug reactions (ADRs) in children in France.
Methods:
In a prospective study over a period of 1 week, we evaluated the incidence of ADRs (1) as a cause of admission to a regional children's hospital; (2) occurring during hospitalization in a regional children's hospital; and (3) as a cause of consultation with private paediatricians.
Results:
Four out of 260 children were admitted to the regional children's hospital for ADRs (1.53% [0.42, 3.89]) and six developed ADRs during hospitalization (2.64% [0.97, 5.66]), 4/428 attended the Accident and Emergency Department for ADRs (0.93% [0.25, 2.37]) and 8/1192 consulted a private paediatrician for ADRs (0.67% [0.29, 1.31]).
Conclusions:
Our results are in agreement with the incidence of ADRs in children found in others countries.