Related Experiment Videos
Epigenetic reprogramming in the mammalian embryo: struggle of the clones
Mellissa R W Mann1, Marisa S Bartolomei
1Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. bartolom@mail.med.upenn.edu
Genome Biology
|February 28, 2002
Abstract:
During preimplantation development in mammals, distinct epigenetic marks on oocyte and sperm DNA are remodeled to an embryonic pattern. A recent study examining global methylation of repetitive elements in various mammals showed that the reprogramming that occurs during normal preimplantation development is aberrant in cloned embryos.