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[A study on relationship between blood lead level and physical growth and development of babies and young children in
1Shanghai Institute for Pediatrics Research, Shanghai Second Medical University, Shanghai 200092.
Insights
Low level lead exposure negatively impacts physical growth in young children. Even mild lead exposure in Shanghai children showed adverse effects on height, weight, and head circumference.
Area of Science:
- Environmental Health
- Pediatrics
- Toxicology
Context:
- Lead exposure is a significant environmental health concern for children globally.
- Assessing the impact of low-level lead exposure on child development is crucial for public health interventions.
Purpose:
- This study investigated the effects of low-level lead exposure on the physical growth and development of young children in Shanghai.
Summary:
- Blood lead levels and physical growth indicators (height, weight, head/chest circumference) were measured in 1,969 children aged 1-6 years.
- Regression analysis revealed a significant inverse correlation between blood lead levels and Z scores for height, weight, and head circumference, even after adjusting for confounding factors.
- A substantial proportion of children (37.8%) had blood lead levels at or above 0.483 micromol/L.
Impact:
- Findings indicate that low-level lead exposure adversely affects physical growth and development in young children.
- Results highlight the need for strategies to reduce lead exposure in urban environments to protect child health.
Objective:
To study the effects of low level lead exposure on physical growth and development in young children.
Methods:
Blood lead level and indicators for physical growth and development, such as body height and weight, and head and chest circumferences were measured in randomly sampled 1,969 children aged 1 - 6 years in Shanghai. Z scores for these indicators were calculated for each of them based on their age and sex-specific norms for children in urban and suburban Shanghai. And, regression analysis of blood lead level was conducted on them.
Results:
Geometric mean of blood lead level was 0.400 micromol/L in young children of Shanghai, and 744 (37.8%) of 1,969 children were equal to or higher than 0.483 micromol/L. Geometric mean of blood lead level correlated in reverse to the Z scores for their body height, weight and head circumference, even if adjusted for the potential confounding factors.
Conclusion:
Low level lead exposure could cause adverse effects on their physical growth and development in young children of Shanghai.
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