[Gastrointestinal alterations in a female patient with common variable immunodeficiency]

Area of Science:

• Gastroenterology
• Immunology

Background:

• Common variable immunodeficiency (CVI) is a primary immunodeficiency characterized by low immunoglobulin levels and impaired B-cell differentiation.
• Gastrointestinal manifestations are frequent in CVI, impacting patient morbidity.

Observation:

• A 33-year-old woman presented with an 8-year history of intermittent diarrhea.
• The patient was diagnosed with common variable immunodeficiency.

Findings:

• Histopathological examination revealed antral atrophic gastritis, partial duodenal villous atrophy, nodular lymphoid hyperplasia of the small intestine, and lymphocytic colitis.
• These findings suggest a link between CVI and diverse gastrointestinal pathologies.

Implications:

• This case underscores the importance of considering CVI in patients with unexplained chronic diarrhea and associated gastrointestinal findings.
• Early diagnosis and management of CVI can potentially mitigate gastrointestinal complications and improve patient outcomes.