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[Double sensitization to PR10 and PR-14 proteins].

L Vanstreels1, G Balakirski, S Röseler

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Summary

A patient experienced anaphylaxis due to hazelnuts and peaches, revealing a double sensitization to specific protein groups. This highlights a growing trend of complex allergy profiles in Europe.

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Area of Science:

  • Allergy and Immunology
  • Clinical Medicine
  • Biochemistry

Background:

  • Oral allergy syndrome (OAS) is a common manifestation of pollen-food allergy syndrome.
  • Anaphylaxis, a severe allergic reaction, can be triggered by various food allergens.
  • Sensitization to specific protein families is a key factor in allergic reactions.

Observation:

  • A patient with mild OAS presented with a history of severe anaphylaxis to hazelnuts and peaches.
  • Diagnostic work-up revealed sensitization to proteins in pathogenesis-related group 10 (PR-10) and group 14 (profilins).
  • This dual sensitization involves proteins like Bet v1, Cor a1, Pru p1 (PR-10) and Pru p3, Cor a8 (profilins).

Findings:

  • The patient exhibited a double sensitization profile to two distinct allergen protein families.
  • This profile links OAS symptoms with a history of severe anaphylaxis to related foods.
  • Identification of specific sensitizing proteins aids in understanding cross-reactivity.

Implications:

  • Double sensitization patterns are increasingly observed, particularly in European populations.
  • Understanding these complex profiles is crucial for accurate diagnosis and effective allergy management.
  • This case underscores the importance of comprehensive allergy testing in patients with severe reactions.