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Cutaneous consequences of photodynamic therapy
Herbert C Wolfsen1, Christine S Ng
1Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA. pdt@mayo.edu
Cutis
|March 1, 2002
Summary
Photodynamic therapy (PDT) can cause skin issues beyond photosensitivity. This study found serious phototoxicity, herpes zoster, and erythema multiforme in patients undergoing PDT for esophageal conditions.
Area of Science:
- Dermatology
- Gastroenterology
- Oncology
Background:
- Photodynamic therapy (PDT) is used for Barrett's esophagus and gastroesophageal cancer.
- Cutaneous complications of PDT are known, but less common ones are rarely reported.
Purpose of the Study:
- To investigate the dermatologic complications of porfimer sodium PDT.
- To assess complications in patients treated for high-grade dysplasia in Barrett's esophagus or gastroesophageal cancer.
Main Methods:
- Retrospective study of 72 consecutive patients treated with porfimer sodium PDT since late 1997.
- Documentation of all reported cutaneous complications.
Main Results:
- 31% of patients experienced serious phototoxicity requiring oral corticosteroids.
- 1% experienced herpes zoster (HZ) requiring hospitalization and IV antiviral treatment.
- 1% experienced erythema multiforme, a drug reaction to porfimer sodium.
Conclusions:
- PDT-associated dermatologic complications are common.
- These complications are not solely related to cutaneous photosensitivity.
- Healthcare providers should be aware of diverse PDT-related skin issues.